Lu Xue-Jing, Zhang Fu-Wen, Cheng Lin, Liu Ai-Qin, Duan Jun-Guo
Key Research Institute for Visual Function Protection with TCM, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
Int J Ophthalmol. 2011;4(4):349-52. doi: 10.3980/j.issn.2222-3959.2011.04.04. Epub 2011 Aug 18.
To observe the effect on multifocal electroretinogram (mfERG) in persistently elevated intraocular pressure (IOP) by erigeron breviscapus extract (also named Dengzhanhua in Chinese) in rat models.
The rat models with persistently elevated IOP were established by the method of Akira. Then, erigeron breviscapus extract was given for one month to observe the effect on mfERG in persistently elevated IOP in rats.
As elevated IOP went on, the mfERG changes were mainly in weaken of reaction density with progressive development. After intervention of erigeron breviscapus extract, the total peak latency of P1 wave had recovered to some extent and the difference was significant when compared with control group (P<0.05); the total response density and P1 wave response density in second circle had risen noticeably, which had significant differences than those of control group (P<0.05).
Erigeron breviscapus extract can improve the impaired visual function of persistently elevated IOP in rats, suggesting that this extract is the effective part of erigeron breviscapus for optic neuroprotection.
观察灯盏花提取物（中药名为灯盏花）对持续性高眼压大鼠模型多焦视网膜电图（mfERG）的影响。
采用秋田法建立持续性高眼压大鼠模型。然后给予灯盏花提取物1个月，观察其对持续性高眼压大鼠mfERG的影响。
随着眼压升高，mfERG变化主要表现为反应密度随病情进展逐渐减弱。灯盏花提取物干预后，P1波的总峰潜时有所恢复，与对照组相比差异有统计学意义（P<0.05）；第二环的总反应密度和P1波反应密度明显升高，与对照组相比有显著差异（P<0.05）。
灯盏花提取物可改善持续性高眼压大鼠受损的视功能，提示该提取物是灯盏花具有视神经保护作用的有效部位。
