Liaoning Inspection, Examination & Certification Centre, Shenyang110036, China.
Liaoning University of Traditional Chinese Medicine, Shenyang110847, China.
Curr Drug Metab. 2021;22(1):24-39. doi: 10.2174/1389200221666201217093255.
Erigeron breviscapus (Vant.) Hand-Mazz. is a plant species in the Compositae family. More than ten types of compounds-such as flavonoids, caffeinate esters, and volatile oils-have been identified in Erigeron breviscapus; however, it remains unknown as to which compounds are associated with clinical efficacy. In recent years, flavonoids and phenolic acids have been considered as the main effective components of Erigeron breviscapus. The metabolism and mechanisms of these compounds in vivo have been extensively studied to improve our understanding of the drug.
In the present review, we summarize the relationships among these compounds, their metabolites, and their pharmacodynamics. Many methods have been implemented to improve the separation and bioavailability of these compounds from Erigeron breviscapus.
In China, Erigeron breviscapus has been used for many years. In recent years, through the study of its metabolism and the mechanisms of its effective components, the effects of Erigeron breviscapus in the treatment of various diseases have been extensively studied. Findings have indicated that Erigeron breviscapus improves cardiovascular and cerebrovascular function and that one of its ingredients, scutellarin, has potential value in the treatment of Alzheimer's disease, cancer, diabetic vascular complications, and other conditions. In addition, phenolic acid compounds and their metabolites also play an important role in anti-oxidation, anti-inflammation, and improving blood lipids.
Erigeron breviscapus plays an important role in the prevention and treatment of cardiovascular/ cerebrovascular diseases, neuroprotection, and cancer through many different mechanisms of action. Further investigation of its efficacious components and metabolites may provide more possibilities for the clinical application of traditional Chinese medicine and the development of novel drugs.
灯盏细辛（Vant.）Hand-Mazz. 是菊科植物。在灯盏细辛中已鉴定出超过十种化合物，如黄酮类、咖啡酸酯和挥发油；然而，尚不清楚哪些化合物与临床疗效有关。近年来，黄酮类和酚酸类被认为是灯盏细辛的主要有效成分。这些化合物在体内的代谢和机制已被广泛研究，以提高我们对药物的认识。
在本综述中，我们总结了这些化合物、它们的代谢物及其药效学之间的关系。已经实施了许多方法来提高这些化合物从灯盏细辛中的分离和生物利用度。
在中国，灯盏细辛已经使用了很多年。近年来，通过对其代谢和有效成分作用机制的研究，广泛研究了灯盏细辛在治疗各种疾病中的作用。研究结果表明，灯盏细辛改善心血管和脑血管功能，其成分之一野黄芩苷在治疗阿尔茨海默病、癌症、糖尿病血管并发症等方面具有潜在价值。此外，酚酸类化合物及其代谢物在抗氧化、抗炎和改善血脂方面也发挥着重要作用。
灯盏细辛通过多种不同的作用机制在预防和治疗心血管/脑血管疾病、神经保护和癌症方面发挥着重要作用。进一步研究其有效成分和代谢物可能为中药的临床应用和新药的开发提供更多可能性。
