Arikan Gul, Osman Saatci Ali, Hakan Oner Ferit
Department of Ophthalmology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
Int J Ophthalmol. 2011;4(4):402-5. doi: 10.3980/j.issn.2222-3959.2011.04.16. Epub 2011 Aug 18.
To evaluate prospectively immediate intraocular pressure (IOP) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide.
Patients who underwent intravitreal injection of 0.1mL (4mg) triamcinolone acetonide (TA, Group T4), 0.05mL (2mg) TA (Group T2) and 0.05mL (0.5mg) ranibizumab (Group R) comprised the study population. Overall, 229 eyes of 205 patients were injected. Fifty-four eyes (23.6%) were in Group T4, 69 eyes (30.1%) in Group T2 and 106 eyes (46.3%) in Group R. If IOP was less than 26mmHg immediately after the injection no further measurement was performed. If IOP was ≥26mmHg, IOP was remeasured till the reading was below 26mmHg at 5, 15 and 30 minutes.
Immediately after the injection, the IOP of 28 eyes (51.9%) in Group T4, 22 eyes (31.9%) in Group T2 and 51 eyes (48.1%) in Group R were over 25mmHg. At 30 minutes, IOP of one eye (1.9%) in group T4, two eyes (2.9%) in group T2 and two eyes (1.9 %) in Group R were over 25mmHg. Immediate post-injection IOP was significantly higher in Group T4 and Group R when compared to Group T2 (P<0.001 and P<0.001, respectively). IOP was significantly higher in eyes without vitreous reflux when compared to those with vitreous reflux in all groups (P<0.001).
IOP may remarkably increase immediately after the intravitreal injection of 2 or 4mg triamcinolone acetonide, and 0.5mg ranibizumab. Absence of vitreous reflux is the most important predicting factor for immediate IOP rise after the injection.
前瞻性评估玻璃体内注射雷珠单抗、2mg和4mg曲安奈德后眼内压（IOP）的即时变化。
接受玻璃体内注射0.1mL（4mg）曲安奈德（TA，T4组）、0.05mL（2mg）TA（T2组）和0.05mL（0.5mg）雷珠单抗（R组）的患者构成研究人群。总共对205例患者的229只眼进行了注射。T4组有54只眼（23.6%），T2组有69只眼（30.1%），R组有106只眼（46.3%）。如果注射后即时眼压低于26mmHg，则不再进行进一步测量。如果眼压≥26mmHg，则在5、15和30分钟时重新测量眼压，直至读数低于26mmHg。
注射后即时，T4组28只眼（51.9%）、T2组22只眼（31.9%）和R组51只眼（48.1%）的眼压超过25mmHg。30分钟时，T4组1只眼（1.9%）、T2组2只眼（2.9%）和R组2只眼（1.9%）的眼压超过25mmHg。与T2组相比，T4组和R组注射后即时眼压显著更高（分别为P<0.001和P<0.001）。在所有组中，无玻璃体反流的眼的眼压显著高于有玻璃体反流的眼（P<0.001）。
玻璃体内注射2mg或4mg曲安奈德以及0.5mg雷珠单抗后，眼压可能会立即显著升高。无玻璃体反流是注射后即时眼压升高的最重要预测因素。
