Guest John-Michael, Malbin Brett, Abrams Gary, Parendo Anthony, Das Shibandri, Okeagu Chinwenwa, Ross Bing X, Kumar Ashok, Lin Xihui
Kresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, 4717 St. Antoine Street, Detroit, MI, 48201, USA.
Int J Retina Vitreous. 2022 Apr 5;8(1):27. doi: 10.1186/s40942-022-00375-3.
To evaluate the accuracy of intravitreal injection volume of the pre-filled syringe (PFS) in which aflibercept is packaged compared to the BD Luer-Lok 1-mL syringe.
Ophthalmologists injected their typical intravitreal volume for aflibercept using either the PFS or BD Luer-Lok 1-mL syringe for 5 times each. The injected fluid was weighed using a micro-scale and converted to volume. The volume of fluid injected was also evaluated when the 0.05 mL line on the PFS was lined up to the tip or base of the dome-shaped plunger.
Injection volume was measured for 12 physicians. The average injected fluid volume was 74.22 ± 15.87 µL for PFS and 53.42 ± 4.61 µL for the BD Luer-Lok 1-mL syringe (p < 0.0001). The average deviation in volume injected for the PFS was higher compared to the BD Luer-Lok 1-mL syringe (11.36 µL vs. 3.35 µL, p < 0.0001). When the PFS was lined up with the tip of the dome-shaped plunger at the 0.05-mL line, the average injected volume was 71.03% higher.
The intravitreal injection volume and variability using the new PFS were significantly higher than the volume injected using the BD Luer-Lok 1-mL syringe previously used, potentially leading to higher rates of visually significant elevation of intraocular pressures.
评估阿柏西普预充式注射器（PFS）与BD鲁尔锁1毫升注射器相比玻璃体内注射体积的准确性。
眼科医生分别使用PFS或BD鲁尔锁1毫升注射器，每次注射其典型的阿柏西普玻璃体内注射体积，各注射5次。使用微量天平对注射的液体进行称重并换算成体积。当PFS上的0.05毫升刻度线与圆顶形柱塞的尖端或底部对齐时，也对注射的液体体积进行评估。
对12名医生的注射体积进行了测量。PFS的平均注射液体体积为74.22±15.87微升，BD鲁尔锁1毫升注射器的平均注射液体体积为53.42±4.61微升（p<0.0001）。与BD鲁尔锁1毫升注射器相比，PFS的平均注射体积偏差更高（11.36微升对3.35微升，p<0.0001）。当PFS在0.05毫升刻度线处与圆顶形柱塞的尖端对齐时，平均注射体积高出71.03%。
使用新型PFS的玻璃体内注射体积和变异性显著高于先前使用的BD鲁尔锁1毫升注射器的注射体积，这可能导致具有临床意义的眼压升高发生率更高。
