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梗阻性分娩和剖宫产:手术干预的代价和收益。

Obstructed labor and caesarean delivery: the cost and benefit of surgical intervention.

机构信息

Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, United States of America.

出版信息

PLoS One. 2012;7(4):e34595. doi: 10.1371/journal.pone.0034595. Epub 2012 Apr 25.

Abstract

BACKGROUND

Although advances in the reduction of maternal mortality have been made, up to 273,000 women will die this year from obstetric etiologies. Obstructed labor (OL), most commonly treated with Caesarean delivery, has been identified as a major contributor to global maternal morbidity and mortality. We used economic and epidemiological modeling to estimate the cost per disability-adjusted life-year (DALY) averted and benefit-cost ratio of treating OL with Caesarean delivery for 49 countries identified as providing an insufficient number of Caesarean deliveries to meet demand.

METHODS AND FINDINGS

Using publicly available data and explicit economic assumptions, we estimated that the cost per DALY (3,0,0) averted for providing Caesarean delivery for OL ranged widely, from $251 per DALY averted in Madagascar to $3,462 in Oman. The median cost per DALY averted was $304. Benefit-cost ratios also varied, from 0.6 in Zimbabwe to 69.9 in Gabon. The median benefit-cost ratio calculated was 6.0. The main limitation of this study is an assumption that lack of surgical capacity is the main factor responsible for DALYs from OL.

CONCLUSIONS

Using the World Health Organization's cost-effectiveness standards, investing in Caesarean delivery can be considered "highly cost-effective" for 48 of the 49 countries included in this study. Furthermore, in 46 of the 49 included countries, the benefit-cost ratio was greater than 1.0, implying that investment in Caesarean delivery is a viable economic proposition. While Caesarean delivery alone is not sufficient for combating OL, it is necessary, cost-effective by WHO standards, and ultimately economically favorable in the vast majority of countries included in this study.

摘要

背景

尽管在降低产妇死亡率方面取得了进展,但今年仍将有 27.3 万名妇女死于产科病因。梗阻性分娩(OL),最常见的治疗方法是剖宫产,已被确定为全球产妇发病率和死亡率的主要原因。我们使用经济和流行病学模型来估计为 49 个被认为剖宫产数量不足以满足需求的国家治疗 OL 的成本效益比,这些国家的每一个残疾调整生命年(DALY)的成本效益比和成本效益比。

方法和发现

使用公开可用的数据和明确的经济假设,我们估计,为 OL 提供剖宫产治疗的每 DALY(3,0,0)的成本效益比从马达加斯加的每 DALY 251 美元到阿曼的 3462 美元不等。中值每 DALY 成本效益比为 304。受益成本比也有所不同,从津巴布韦的 0.6 到加蓬的 69.9。计算出的中值受益成本比为 6.0。这项研究的主要限制是假设缺乏手术能力是 OL 导致 DALY 的主要因素。

结论

根据世界卫生组织的成本效益标准,在这项研究包括的 49 个国家中,对剖宫产的投资可以被认为是“非常具有成本效益的”。此外,在包括的 49 个国家中的 46 个国家中,受益成本比大于 1.0,这意味着对剖宫产的投资是一个可行的经济主张。虽然剖宫产本身不足以治疗 OL,但它是必要的,按照世卫组织的标准具有成本效益,并且在这项研究包括的绝大多数国家中最终具有经济优势。

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