溶血磷脂酸在神经系统中的生物学效应。

Biological effects of lysophosphatidic acid in the nervous system.

机构信息

Department of Ophthalmology, The University of Melbourne, East Melbourne, Victoria, Australia.

出版信息

Int Rev Cell Mol Biol. 2012;296:273-322. doi: 10.1016/B978-0-12-394307-1.00005-9.

Abstract

Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular effects in various cell types, leading to a variety of responses in tissues, including in the nervous system. LPA and its receptors are found in the nervous system, with different cellular and temporal profiles. Through its ability to target most cells of the nervous system and its induction of pleiotropic effects, LPA mediates events during neural development and adulthood. In this review, we summarize the current knowledge on the effects of LPA in the nervous system, during development and adulthood, and in various pathologies of the nervous system. We also explore potential LPA intervention strategies for anti-LPA therapeutics.

摘要

溶血磷脂酸（LPA）是一种生物活性脂质，可调节各种细胞类型中广泛的细胞效应，导致组织中产生各种反应，包括神经系统。LPA 和其受体存在于神经系统中，具有不同的细胞和时间特征。通过靶向神经系统的大多数细胞及其诱导的多效性效应，LPA 介导神经发育和成年期的事件。在这篇综述中，我们总结了目前关于 LPA 在神经系统发育和成年期以及神经系统各种疾病中的作用的知识。我们还探讨了潜在的 LPA 干预策略，以用于抗 LPA 治疗。