家庭传播 2009 年甲型 H1N1 流感：系统评价和荟萃分析。

Household transmission of 2009 pandemic influenza A (H1N1): a systematic review and meta-analysis.

机构信息

School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

出版信息

Epidemiology. 2012 Jul;23(4):531-42. doi: 10.1097/EDE.0b013e31825588b8.

BACKGROUND

During the 2009 influenza A (H1N1) pandemic, household transmission studies were implemented to better understand the characteristics of the transmission of the novel virus in a confined setting.

METHODS

We conducted a systematic review and meta-analysis to assess and summarize the findings of these studies. We identified 27 articles, around half of which reported studies conducted in May and June 2009.

RESULTS

In 13 of the 27 studies (48%) that collected respiratory specimens from household contacts, point estimates of the risk of secondary infection ranged from 3% to 38%, with substantial heterogeneity. Meta-regression analyses revealed that a part of the heterogeneity reflected varying case ascertainment and study designs. The estimates of symptomatic secondary infection risk, based on 20 studies identifying febrile acute respiratory illness among household contacts, also showed substantial variability, with point estimates ranging from 4% to 37%.

CONCLUSIONS

Transmission of the 2009 pandemic virus in households appeared to vary among countries and settings, with differences in estimates of the secondary infection risk also partly due to differences in study designs.

背景

在 2009 年甲型 H1N1 流感大流行期间，实施了家庭传播研究，以更好地了解新型病毒在封闭环境中的传播特征。

方法

我们进行了系统评价和荟萃分析，以评估和总结这些研究的结果。我们确定了 27 篇文章，其中约有一半报告了 2009 年 5 月和 6 月进行的研究。

结果

在 27 项收集家庭接触者呼吸道标本的研究中（48%），次要感染风险的点估计值范围为 3%至 38%，存在很大的异质性。Meta 回归分析表明，部分异质性反映了不同的病例确定和研究设计。基于 20 项研究确定家庭接触者发热急性呼吸道疾病的研究，对有症状的继发感染风险的估计也显示出很大的可变性，点估计值范围为 4%至 37%。