Laboratory of Regenerative Neurosciences, Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Neurosci Res. 2012 Jul;73(3):263-8. doi: 10.1016/j.neures.2012.04.005. Epub 2012 Apr 24.
Exposure of the fetal brain to ionizing radiation causes congenital brain abnormalities. Normal brain formation requires regionally and temporally appropriate proliferation and differentiation of neural stem cells (NSCs) into neurons and glia. Here, we investigated the effects of X-irradiation on proliferating homogenous NSCs prepared from mouse ES cells. Cells irradiated with X-rays at a dose of 1Gy maintained the capabilities for proliferation and differentiation but stopped proliferation temporarily. In contrast, the cells ceased proliferation following irradiation at a dose of >5Gy. These results suggest that irradiation of the fetal brain at relatively low doses may cause congenital brain abnormalities as with relatively high doses.
胎儿大脑暴露于电离辐射会导致先天性脑异常。正常的大脑形成需要神经干细胞（NSC）在区域和时间上适当增殖和分化为神经元和胶质细胞。在这里，我们研究了 X 射线照射对从小鼠胚胎干细胞中制备的增殖同源 NSC 的影响。用 1Gy 剂量的 X 射线照射的细胞保持增殖和分化的能力，但暂时停止增殖。相比之下，细胞在剂量大于 5Gy 的照射后停止增殖。这些结果表明，与高剂量照射一样，胎儿大脑的低剂量照射可能导致先天性脑异常。
