Huang Lixiang, Wang Gan
Department of Chemistry and Biology, College of Science, National University of Defense Technology, Changsha, Hunan 410073, China.
Stem Cells Int. 2017;2017:9497325. doi: 10.1155/2017/9497325. Epub 2017 Nov 20.
The repair of central nervous system (CNS) injury has been a worldwide problem in the biomedical field. How to reduce the damage to the CNS and promote the reconstruction of the damaged nervous system structure and function recovery has always been the concern of nerve tissue engineering. Multiple differentiation potentials of neural stem cell (NSC) determine the application value for the repair of the CNS injury. Thus, how to regulate the behavior of NSCs becomes the key to treating the CNS injury. So far, a large number of researchers have devoted themselves to searching for a better way to regulate the behavior of NSCs. This paper summarizes the effects of different factors on the behavior of NSCs in the past 10 years, especially on the proliferation and differentiation of NSCs. The final purpose of this review is to provide a more detailed theoretical basis for the clinical repair of the CNS injury by nerve tissue engineering.
中枢神经系统（CNS）损伤的修复一直是生物医学领域的一个全球性问题。如何减少对中枢神经系统的损伤并促进受损神经系统结构的重建和功能恢复一直是神经组织工程关注的焦点。神经干细胞（NSC）的多向分化潜能决定了其在中枢神经系统损伤修复中的应用价值。因此，如何调控神经干细胞的行为成为治疗中枢神经系统损伤的关键。到目前为止，大量研究人员致力于寻找更好的方法来调控神经干细胞的行为。本文总结了过去10年中不同因素对神经干细胞行为的影响，特别是对神经干细胞增殖和分化的影响。本综述的最终目的是为神经组织工程临床修复中枢神经系统损伤提供更详细的理论依据。
