Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.
Fitoterapia. 2012 Jul;83(5):968-72. doi: 10.1016/j.fitote.2012.04.020. Epub 2012 Apr 27.
A new flavanone derivative, malaysianone A (1), four prenylated flavanones, 6-prenyl-3'-methoxyeriodictyol (2), nymphaeol B (3), nymphaeol C (4) and 6-farnesyl-3',4',5,7-tetrahydroxyflavanone (5), and two coumarins, 5,7-dihydroxycoumarin (6) and scopoletin (7), were isolated from the dichloromethane extract of the inflorescences of Macaranga triloba. The structures of these compounds were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR and mass spectrometry. The cytotoxic activity of the compounds was tested against several cell lines, with 5 inhibiting very strongly the growth of HeLa and HL-60 cells (IC(50): 1.3 μg/ml and 3.3 μg/ml, respectively). Compound 5 also showed strong antiplasmodial activity (IC(50): 0.06 μM).
从三叶崖爬藤的花序的二氯甲烷提取物中分离得到一个新的黄烷酮衍生物，马来西亚酮 A（1），四个prenylated flavanones，6-prenyl-3'-methoxyeriodictyol（2），水仙醇 B（3），水仙醇 C（4）和 6-香叶基-3'，4'，5，7-四羟基黄烷酮（5），和两个香豆素，5,7-二羟基香豆素（6）和东莨菪内酯（7）。这些化合物的结构是根据包括核磁共振（NMR-1D 和 2D）、UV、IR 和质谱在内的光谱方法阐明的。对化合物的细胞毒性活性进行了测试，结果表明，化合物 5 对 HeLa 和 HL-60 细胞的生长有很强的抑制作用（IC（50）：1.3 μg/ml 和 3.3 μg/ml）。化合物 5 还表现出很强的抗疟原虫活性（IC（50）：0.06 μM）。
