University of Tübingen, Centre for Ophthalmology, Tübingen, Germany.
Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3748-55. doi: 10.1167/iovs.11-9409.
To optimize methods for positioning subretinal visual implants, customizing their cable length, guiding them to the predetermined retinal position, and evaluating their performance.
Ten eyes of 10 patients (6 male, 4 female, mean age 46.4 years) were investigated before implantation of a subretinal visual implant. The structural characteristics of the retina as well as the ocular dimensions were determined. Topographic images of the prospective implantation site were subdivided into grids of squares. Each square received a weighted score for suitability. The sum of the scores was calculated, and the region with the highest score was chosen for the implant. In each case, the implant's power supply cable length was calculated by means of magnetic resonance imaging. The planned and achieved positions before and after implantation were compared.
The mean light sensitivity ratio between the area actually covered by the chip and that of the planned position was 90.8% with an SD of 11.4%. In two cases with almost perfect positioning, the computed ratio was 100%. Measurements showed that to achieve a 95% sensitivity rate the difference between the planned and achieved chip position must be less than 1.7 mm. Preoperative calculations of the intraocular cable length proved accurate in all cases.
Preoperative evaluation of retinal structures and eye morphology is useful for guiding a retinal implant to the designated area. It is a meaningful tool for planning and performing retinal chip implantation, and it optimizes personalized implantation. (ClinicalTrials.gov numbers, NCT00515814, NCT01024803.).
优化视网膜下视觉植入物的定位方法，定制其电缆长度，将其引导至预定的视网膜位置，并评估其性能。
在植入视网膜下视觉植入物之前，对 10 名患者（6 名男性，4 名女性，平均年龄 46.4 岁）的 10 只眼睛进行了研究。确定了视网膜的结构特征和眼球尺寸。将预期植入部位的地形图像细分为正方形网格。每个正方形都获得了适合度的加权分数。计算分数总和，并选择得分最高的区域进行植入。在每种情况下，通过磁共振成像计算植入物的电源电缆长度。比较植入前后的计划和实际位置。
实际覆盖芯片区域与计划位置之间的平均光灵敏度比为 90.8%，标准差为 11.4%。在两个位置几乎完全相同的情况下，计算出的比率为 100%。测量结果表明，要达到 95%的灵敏度，计划和实际芯片位置之间的差异必须小于 1.7 毫米。所有情况下，术前计算的眼内电缆长度都证明是准确的。
术前评估视网膜结构和眼形态对于将视网膜植入物引导至指定区域非常有用。它是规划和执行视网膜芯片植入的有意义工具，可以优化个性化植入。（临床试验.gov 编号，NCT00515814，NCT01024803）。
