Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2012 May;27(5):484-8. doi: 10.3346/jkms.2012.27.5.484. Epub 2012 Apr 25.
The elastin metabolism in systemic sclerosis (SSc) has been known to be abnormal. The authors investigated relationship between the clinical manifestations of systemic sclerosis (SSc) and serum levels of soluble elastin-derived peptide (S-EDP) and anti-elastin antibodies. Serum samples were obtained from 79 patients with SSc and 79 age- and sex-matched healthy controls. Concentrations of serum S-EDP and anti-elastin antibodies were measured by ELISA. The serum concentrations of S-EDP in SSc patients were significantly higher than in healthy controls (median, 144.44 ng/mL vs 79.59 ng/mL, P < 0.001). Serum EDP concentrations were found to be correlated with disease duration in SSc (P = 0.002) and particularly in diffuse cutaneous SSc (P = 0.005). Levels of anti-elastin antibodies were found to be more elevated in SSc patients than in healthy controls (median, 0.222 U vs 0.191 U, P = 0.049), more increased in diffuse cutaneous SSc than limited cutaneous SSc (median, 0.368 U vs 0.204 U, P = 0.031). In addition, levels of anti-elastin antibodies were also found to be negatively associated with presence of anti-centromere antibody (P = 0.023). The S-EDP levels were not found to be correlated with levels of anti-elastin antibodies. The increased S-EDP and anti-elastin antibody levels and association with clinical and laboratory characteristics may reflect the abnormal metabolism in SSc.
系统性硬化症（SSc）的弹性蛋白代谢异常已被人们所熟知。作者研究了系统性硬化症（SSc）的临床表现与血清可溶性弹性蛋白衍生肽（S-EDP）和抗弹性蛋白抗体水平之间的关系。从 79 例 SSc 患者和 79 名年龄和性别匹配的健康对照者中采集血清样本。采用 ELISA 法检测血清 S-EDP 和抗弹性蛋白抗体浓度。SSc 患者血清 S-EDP 浓度明显高于健康对照组（中位数 144.44ng/ml 比 79.59ng/ml，P＜0.001）。SSc 患者血清 EDP 浓度与疾病病程有关（P＝0.002），尤其是弥漫性皮肤型 SSc（P＝0.005）。抗弹性蛋白抗体水平在 SSc 患者中高于健康对照组（中位数 0.222U 比 0.191U，P＝0.049），弥漫性皮肤型 SSc 高于局限性皮肤型 SSc（中位数 0.368U 比 0.204U，P＝0.031）。此外，抗弹性蛋白抗体水平还与抗着丝点抗体呈负相关（P＝0.023）。S-EDP 水平与抗弹性蛋白抗体水平无相关性。S-EDP 和抗弹性蛋白抗体水平的增加与临床和实验室特征有关，可能反映了 SSc 的异常代谢。
