系统性硬化症患者血清中多形核中性粒细胞弹性蛋白酶浓度升高：与肺纤维化的关联
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
作者信息
Hara Toshihide, Ogawa Fumihide, Yanaba Koichi, Iwata Yohei, Muroi Eiji, Komura Kazuhiro, Takenaka Motoi, Shimizu Kazuhiro, Hasegawa Minoru, Fujimoto Manabu, Sato Shinichi
机构信息
Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
出版信息
J Rheumatol. 2009 Jan;36(1):99-105. doi: 10.3899/jrheum.080269.
OBJECTIVE
To determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc).
METHODS
Serum PMN elastase levels from 21 patients with limited cutaneous SSc (lSSc) and 32 with diffuse cutaneous SSc (dSSc) were examined by ELISA.
RESULTS
Serum PMN elastase levels were elevated in patients with SSc, especially dSSc, compared to healthy controls. SSc patients with elevated serum PMN elastase levels had more frequent presence of pulmonary fibrosis, arthritis, contracture of phalanges, and diffuse pigmentation. Anticentromere antibody was detected less frequently in SSc patients with elevated serum PMN elastase levels than in controls. Consistently, serum PMN elastase levels also correlated positively with serum levels of KL-6 and surfactant protein-D, serological markers for pulmonary fibrosis. Serum PMN elastase levels were also associated with levels of serum 8-isoprostane, an oxidative stress marker in SSc.
CONCLUSION
Serum PMN elastase levels were elevated in patients with SSc, and it was more prominent in patients with pulmonary fibrosis, suggesting that serum PMN elastase is a novel serological marker for SSc-related pulmonary fibrosis.
目的
测定系统性硬化症（SSc）患者血清中多形核中性粒细胞（PMN）弹性蛋白酶的浓度及其临床相关性。
方法
采用酶联免疫吸附测定法（ELISA）检测21例局限性皮肤型SSc（lSSc）患者和32例弥漫性皮肤型SSc（dSSc）患者的血清PMN弹性蛋白酶水平。
结果
与健康对照相比，SSc患者血清PMN弹性蛋白酶水平升高，尤其是dSSc患者。血清PMN弹性蛋白酶水平升高的SSc患者出现肺纤维化、关节炎、指关节挛缩和弥漫性色素沉着的频率更高。血清PMN弹性蛋白酶水平升高的SSc患者抗着丝点抗体的检出频率低于对照组。同样，血清PMN弹性蛋白酶水平也与肺纤维化的血清学标志物KL-6和表面活性蛋白-D的水平呈正相关。血清PMN弹性蛋白酶水平还与SSc中氧化应激标志物血清8-异前列腺素的水平相关。
结论
SSc患者血清PMN弹性蛋白酶水平升高，在肺纤维化患者中更为明显，提示血清PMN弹性蛋白酶是SSc相关肺纤维化的一种新型血清学标志物。
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