饮食抗氧化剂与前列腺癌：综述。
Dietary antioxidants and prostate cancer: a review.
机构信息
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA.
出版信息
Nutr Cancer. 2013;65(6):793-801. doi: 10.1080/01635581.2013.806672.
Abstract
Prostate cancer is the most common noncutaneous cancer in men in the United States. Several studies have examined the relationship between prostate cancer and antioxidants; however, the results of these studies are inconsistent. This article provides a systematic review of studies on prostate cancer and antioxidant intake from diet and supplements. Tea and coffee appear to offer protection against advanced prostate cancer. Different forms of vitamin E appear to exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease. There is no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, whereas lycopene appears to be negatively associated with risk of the disease. The effect of dietary antioxidants on prostate cancer remains undefined and inconclusive, with different antioxidants affecting prostate cancer risk differentially. Further studies are needed to clarify the relationship between antioxidants and prostate cancer risk and to delineate the underlying mechanisms.
摘要
在美国，前列腺癌是男性中最常见的非皮肤癌。有几项研究探讨了前列腺癌与抗氧化剂之间的关系，但这些研究的结果并不一致。本文对来自饮食和补充剂的前列腺癌和抗氧化剂摄入的研究进行了系统综述。茶和咖啡似乎对晚期前列腺癌有保护作用。不同形式的维生素 E 似乎对前列腺癌有不同的影响，α-生育酚可能会增加疾病的风险，而γ-生育酚可能会降低风险。硒、维生素 C 或β-胡萝卜素没有明显的有益作用，而番茄红素与疾病的风险呈负相关。膳食抗氧化剂对前列腺癌的影响仍不明确和不确定，不同的抗氧化剂对前列腺癌风险的影响也不同。需要进一步的研究来阐明抗氧化剂与前列腺癌风险之间的关系，并阐明潜在的机制。
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