Li Shaoying, Yan Zhijie, Jhala Nirag, Jhala Darshana
Cytojournal. 2010 Jul 2;7:12. doi: 10.4103/1742-6413.65058.
Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease (RDD) is an uncommon but well-defined benign self-limited clinicopathological entity. It mainly involves lymph nodes. Extranodal involvement is seen in up to 43% of cases, with the most common location in the head and neck region. Primary RDD occurring in the bone is rare with only twelve cases reported in the literature to date, all diagnosed on histology except one by fine needle aspiration (FNA) cytology. We report a case of RDD diagnosed by FNA cytology in a 28 year-old female presented as an osteolytic lesion of superior pubic ramus where the differential diagnosis included a sarcoma and lymphoma. Based on the cytologic findings, a diagnosis of a RDD was considered during the rapid FNA on site with no clinical history provided. The diagnosis of RDD was further confirmed by immunohistochemical stains and histology diagnosis. Our findings show that even in the absence of a clinical history, FNA is a less invasive and a very reliable tool for the diagnosis of SHML (RDD).
伴有巨大淋巴结病的窦组织细胞增生症（SHML）或罗萨伊-多夫曼病（RDD）是一种罕见但明确的良性自限性临床病理实体。它主要累及淋巴结。结外受累见于高达43%的病例，最常见于头颈部区域。原发性RDD发生于骨骼者罕见，迄今为止文献中仅报道了12例，除1例通过细针穿刺（FNA）细胞学诊断外，其余均经组织学诊断。我们报告1例28岁女性患者，通过FNA细胞学诊断为RDD，表现为耻骨上支溶骨性病变，鉴别诊断包括肉瘤和淋巴瘤。基于细胞学发现，在现场快速FNA时考虑诊断为RDD，当时未提供临床病史。RDD诊断通过免疫组化染色和组织学诊断进一步得到证实。我们的研究结果表明，即使没有临床病史，FNA也是诊断SHML（RDD）的一种侵入性较小且非常可靠的工具。
