初步蛋白质羰基化在细胞信号转导中的作用。
Proposed role of primary protein carbonylation in cell signaling.
机构信息
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA.
出版信息
Redox Rep. 2012;17(2):90-4. doi: 10.1179/1351000212Y.0000000007.
Abstract
Reactive oxygen species (ROS) mediate various cell signaling processes, but the mechanism for how ROS promote cell signaling is poorly understood. Protein carbonylation occurs because of the direct metal-catalyzed oxidation of amino acid side chains (primary protein carbonylation) or the addition of reactive aldehydes to amino acid side chains (secondary protein carbonylation). We hypothesize that primary protein carbonylation plays a role in the mechanism of ROS signaling. Specifically, we propose that (i) primary protein carbonylation mediates cell signaling and (ii) primary protein carbonylation is reversible.
摘要
活性氧（ROS）介导各种细胞信号转导过程，但 ROS 促进细胞信号转导的机制尚不清楚。蛋白质羰基化是由于氨基酸侧链的直接金属催化氧化（主要蛋白质羰基化）或反应性醛添加到氨基酸侧链（次要蛋白质羰基化）引起的。我们假设主要蛋白质羰基化在 ROS 信号转导机制中起作用。具体来说，我们提出（i）主要蛋白质羰基化介导细胞信号转导，（ii）主要蛋白质羰基化是可逆的。
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