Collett M S, Brugge J S, Erikson R L, Lau A F, Krzyzek R A, Faras A J
Nature. 1979 Sep 20;281(5728):195-8. doi: 10.1038/281195a0.
Morphological revertants of avian sarcoma virus transformed vole cells contain the sarcoma gene product (pp60src) in an enzymatically active form, suggesting that the presence of pp60src protein kinase activity is infussicient to induce morphological transformation. Structural analyses of pp60src from infected vole cell clones suggest that in one of the revertant clones on alteration in pp60src may be responsible for morphological reversion while in a second clone, reversion may result from an alteration in a cell gene product with which pp60src must interact. As these morphological revertant cells are tumorigenic, different cell components are required to interact with pp60src to facilitate the two events.
禽肉瘤病毒转化的田鼠细胞的形态学回复突变体含有酶活性形式的肉瘤基因产物（pp60src），这表明pp60src蛋白激酶活性的存在不足以诱导形态学转化。对来自受感染田鼠细胞克隆的pp60src的结构分析表明，在一个回复突变体克隆中，pp60src的改变可能是形态学回复的原因，而在另一个克隆中，回复可能是由于与pp60src相互作用的细胞基因产物的改变。由于这些形态学回复突变细胞具有致瘤性，因此需要不同的细胞成分与pp60src相互作用以促进这两个事件。
