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使用光谱域光学相干断层扫描对人体口腔组织进行无创体内结构和血管成像。

Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography.

作者信息

Davoudi Bahar, Lindenmaier Andras, Standish Beau A, Allo Ghassan, Bizheva Kostadinka, Vitkin Alex

出版信息

Biomed Opt Express. 2012 May 1;3(5):826-39. doi: 10.1364/BOE.3.000826. Epub 2012 Apr 2.

DOI:10.1364/BOE.3.000826
PMID:22567578
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3342190/
Abstract

A spectral domain optical coherence tomography (SD-OCT) system and an oral imaging probe have been developed to visualize the microstructural morphology and microvasculature in the human oral cavity. Structural OCT images of ex vivo pig oral tissues with the histology of the same sites were acquired and compared for correlations. Structural in vivo OCT images of healthy human tissue as well as a pathologic site (ulcer) were obtained and analyzed based on the results of the ex vivo pig study, drawing on the similarity between human and swine oral tissues. In vivo Doppler and speckle variance OCT images of the oral cavity in human volunteers were also acquired, to demonstrate the feasibility of microvascular imaging of healthy and pathologic (scar) oral tissue.

摘要

已开发出一种光谱域光学相干断层扫描（SD-OCT）系统和一种口腔成像探头，用于可视化人体口腔中的微观结构形态和微血管系统。采集了离体猪口腔组织相同部位的组织学结构OCT图像，并进行比较以寻找相关性。基于离体猪研究的结果，利用人类和猪口腔组织之间的相似性，获取并分析了健康人体组织以及病理部位（溃疡）的活体结构OCT图像。还采集了人类志愿者口腔的活体多普勒和散斑方差OCT图像，以证明对健康和病理（瘢痕）口腔组织进行微血管成像的可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/5919d57016c1/boe-3-5-826-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/828a145d2564/boe-3-5-826-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/7708966676d6/boe-3-5-826-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/38eac5b77580/boe-3-5-826-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/b83d09757168/boe-3-5-826-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/7f3525feaace/boe-3-5-826-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/1ab99cb30e26/boe-3-5-826-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/e51db14db482/boe-3-5-826-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/5919d57016c1/boe-3-5-826-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/828a145d2564/boe-3-5-826-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/7708966676d6/boe-3-5-826-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/38eac5b77580/boe-3-5-826-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/b83d09757168/boe-3-5-826-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/7f3525feaace/boe-3-5-826-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/1ab99cb30e26/boe-3-5-826-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/e51db14db482/boe-3-5-826-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d320/3342190/5919d57016c1/boe-3-5-826-g008.jpg

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