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菊科一些药用植物对J-45.01白血病细胞系的细胞毒性作用——初步研究

Cytotoxic effect of some medicinal plants from Asteraceae family on J-45.01 leukemic cell line--pilot study.

作者信息

Wegiera Magdalena, Smolarz Helena D, Jedruch Marcin, Korczak Magdalena, Koproń Kamila

机构信息

Department of Pharmaceutical Botany, Medical University, 20-093 Lublin, Poland.

出版信息

Acta Pol Pharm. 2012 Mar-Apr;69(2):263-8.

Abstract

In this study the in vitro cytotoxic properties of ethanol extracts from the herbs, inflorescents and roots of selected Asteraceae species: Arctium lappa, Artemisia absinthium, Calendula officinalis, Centaurea cyanus, Tanacetum vulgare and Tragopogon pratensis on J-45.01 human acute T leukemia cell line was examined. All tested samples possess antileukemic properties and induce cells death via apoptosis. The correlation between antileukemic activity and total polyphenol content was determined.

摘要

在本研究中,检测了菊科选定物种牛蒡、苦艾、金盏花、矢车菊、艾菊和草地婆罗门参的叶、花和根的乙醇提取物对J-45.01人急性T白血病细胞系的体外细胞毒性。所有测试样品均具有抗白血病特性,并通过凋亡诱导细胞死亡。测定了抗白血病活性与总多酚含量之间的相关性。

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