Elucidating the antimicrobial and anticarcinogenic potential of methanolic and water extracts of edible Boiss.

is a pharmacotherapeutic herbaceous plant belonging to the Asteraceae family and consumed as a vegetable. Here, the methanolic and water extracts of were obtained from its aboveground parts (stem, leaves, and flowers), and the phytochemical potentials were investigated by LC-HRMS (liquid chromatography-high resolution mass spectrometry) analysis for the first time. The antibacterial, antifungal, and anticarcinogenic activities of extracts were investigated using experimental and in silico methods. methanol extract revealed remarkable inhibitory activity against , , and (MICs = 0.83, 1.67, and 1.67 mg/mL, respectively) compared to and (MIC = 53.3 mg/mL). Inhibitory effects of methanolic extracts were also observed in all species tested, with the highest inhibition on (MIC = 0.83 mg/mL), whereas no inhibitory effect was identified from the water extract. Additionally, both methanolic (IC50 = 86 μg/mL) and water (IC50 = 92 μg/mL) extracts revealed significant selective anticarcinogenic effects on AR42J pancreatic cancer cells. HeLa and MDA-MB-231 cells were, however, more resilient to methanol and water extract, respectively. In silico analyses further elucidated the noteworthy antibacterial potential of keracyanin chloride on MurB enzyme and the remarkable inhibitory potential of naringin on FYN kinase specific for pancreatic cancer (AR42J) development. In conclusion, phytochemicals with antibacterial, antifungal, and anticancer properties were revealed for the first time, and molecular docking studies on potential targets confirmed good agreement with experimental findings. Therefore, the current studies on provide the basis for investigating new pharmaceutical potentials of other members.