Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
BJOG. 2012 Jul;119(8):936-44. doi: 10.1111/j.1471-0528.2012.03344.x. Epub 2012 May 9.
To assess the health-related quality of life (HRQoL) impact of cervical cancer screening in women with normal test results.
Questionnaire study.
Maastricht, the Netherlands.
A cohort of 789 women were followed from screening invitation until after the receipt of screening results. A female age-matched reference group (n=567) was included.
Questionnaires were sent to the home address of the women before screening, after screening, and again with the screening results.
Generic HRQoL (SF-12, EQ-5D), generic anxiety (STAI-6), screen-specific anxiety (PCQ), and potential symptoms and feelings related to the smear-taking procedure.
A total of 60% of screening participants completed questionnaire 1(n=924): 803 of these women granted permission to access their files; 789 of these 803 women had normal test results (Pap 1), and were included in the analyses. Generic HRQoL (SF-12, EQ-5D) and anxiety (STAI-6) scores were similar in the study and reference groups. Before screening, after screening, and also after the receipt of test results, screening participants reported less screen-specific anxiety (PCQ, P<0.001) than the reference group (n=567), with differences indicating clinical relevance. 19% of screening participants were bothered by feelings of shame, pain, inconvenience, or nervousness during smear taking, and 8 and 5% of women experienced lower abdominal pain, vaginal bleeding, discharge, or urinary problems for 2-3 and 4-7 days, respectively, following the Pap smear.
The reduced levels of screen-specific anxiety in screening participants, possibly indicating reassurance, are worthwhile addressing in more depth. We conclude that although considerable numbers of women reported unpleasant effects, there were no adverse HRQoL consequences of cervical screening in women with normal test results.
评估宫颈癌筛查对正常检查结果女性的健康相关生活质量（HRQoL）的影响。
问卷调查研究。
荷兰马斯特里赫特。
从筛查邀请到收到筛查结果，对 789 名女性进行了随访。还纳入了一个年龄匹配的女性参考组（n=567）。
在筛查前、筛查后和收到筛查结果后，将问卷发送到女性的家庭住址。
一般健康相关生活质量（SF-12、EQ-5D）、一般焦虑（STAI-6）、筛查特异性焦虑（PCQ），以及与宫颈抹片检查相关的潜在症状和感受。
共有 60%的筛查参与者完成了问卷 1（n=924）：其中 803 名妇女同意查阅她们的档案；在这 803 名妇女中，789 名妇女的检查结果正常（巴氏涂片 1），并被纳入分析。研究组和参考组的一般健康相关生活质量（SF-12、EQ-5D）和焦虑（STAI-6）评分相似。在筛查前、筛查后和收到检查结果后，筛查参与者报告的筛查特异性焦虑（PCQ，P<0.001）低于参考组（n=567），差异具有临床意义。19%的筛查参与者在宫颈抹片检查期间感到羞耻、疼痛、不便或紧张，8%和 5%的女性分别在巴氏涂片后 2-3 天和 4-7 天出现下腹痛、阴道出血、分泌物或排尿问题。
筛查参与者的筛查特异性焦虑水平降低，这可能表明他们得到了安抚，值得更深入地探讨。我们的结论是，尽管相当多的女性报告了不愉快的影响，但正常检查结果的女性进行宫颈癌筛查并没有对健康相关生活质量产生不利影响。
