登革热病毒对人体固有免疫系统的逃避。
Evasion of the human innate immune system by dengue virus.
机构信息
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.
出版信息
Immunol Res. 2012 Dec;54(1-3):152-9. doi: 10.1007/s12026-012-8334-2.
Abstract
Dengue virus is a worldwide health problem, with billions of people at risk annually. Dengue virus causes a spectrum of diseases, namely dengue fever, dengue hemorrhagic fever and dengue shock syndrome with the latter two being linked to death. Understanding how dengue is able to evade the immune system and cause enhanced severity of disease is the main topics of interest in the Fernandez-Sesma laboratory at Mount Sinai School of Medicine. Using primary human immune cells, our group investigates the contribution of dengue virus-specific proteins to the evasion of innate immunity by this virus and the host factors that the virus interacts with in order to evade immune recognition and to establish infection in humans. Here, we review recent findings from our group as well as published data from other groups regarding immune modulation by dengue virus.
摘要
登革热病毒是一个全球性的健康问题，每年有数十亿人面临风险。登革热病毒会引起一系列疾病，包括登革热、登革出血热和登革休克综合征，后两种疾病与死亡有关。了解登革热病毒如何逃避免疫系统并导致疾病加重是西奈山医学院费尔南德斯-塞斯马实验室关注的主要课题。我们的研究小组使用原代人免疫细胞，研究登革热病毒特异性蛋白对该病毒逃避先天免疫的贡献，以及病毒为了逃避免疫识别并在人类中建立感染而与之相互作用的宿主因子。在这里，我们回顾了我们小组的最新发现以及其他小组发表的数据，这些数据涉及登革热病毒的免疫调节。
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