Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland.
Dent Mater. 2012 Aug;28(8):e110-7. doi: 10.1016/j.dental.2012.04.026. Epub 2012 May 8.
The purpose of this study was to prepare antibacterial and radiopaque dental resin through adding one polymerizable quaternary ammonium compound with iodine as counter anion into Bis-GMA/TEGDMA (50/50, wt/wt) dental resin system, and evaluate the degree of monomer conversion, mechanical properties, radiopacity, and antibacterial effectiveness of the polymer.
2-Dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) (3 wt.% and 5 wt.%) was added into a Bis-GMA/TEGDMA (50/50, wt/wt) resin system with CQ (0.7 wt.%) and DMAEMA (0.7 wt.%) as photoinitiation system. Degree of monomer conversion (DC) was determined by FT-IR analysis. The flexural strength (FS) and flexural modulus (FM) of the polymer were measured using a three-point bending set up. Radiographs were taken to determine the radiopacity of the polymer, and aluminum step-wedge (0.5-4mm) was used as calibration standard. A single-species biofilm model with Streptococcus mutans as the tests organism was used to evaluate the antibacterial property of the polymer. Bis-GMA/TEGDMA without DDMAI was used as control material in all of the tests.
ANOVA analysis revealed that there was no significant difference in DC between polymer with and without DDMAI (p>0.05). Polymer with 3 wt.% DDMAI had higher FS than the control material (p<0.05), while polymer with 5 wt.% DDMAI had comparable FS with the control material (p>0.05). Though average FM of control material was lower than that of 3 wt.% DDMAI containing polymer and higher than 5 wt.% DDMAI containing polymer, but the differences were statistically insignificant. By increasing the quantity of DDMAI, the radiopacity of the polymer increased. Of the three formulations, the polymer with 5 wt.% DDMAI inhibited biofilm the formation of the clinically relevant young biofilm.
Incorporation of DDMAI into resin system could endow it with radiopacity and antibacterial effectiveness, and these two properties seem to be improved with increasing the quantities of DDMAI.
本研究旨在通过将一种可聚合的季铵盐化合物与碘作为抗衡阴离子添加到 Bis-GMA/TEGDMA（50/50，重量/重量）牙科树脂系统中，制备具有抗菌和射线可透性的牙科树脂，并评估聚合物的单体转化率、力学性能、射线可透性和抗菌效果。
将 2-二甲基-2-十二烷基-1-甲基丙烯酰氧基乙基铵碘（DDMAI）（3wt.%和 5wt.%）添加到含有 CQ（0.7wt.%）和 DMAEMA（0.7wt.%）的 Bis-GMA/TEGDMA（50/50，重量/重量）树脂系统中，作为光引发剂。通过傅里叶变换红外分析（FT-IR）测定单体转化率（DC）。使用三点弯曲装置测量聚合物的弯曲强度（FS）和弯曲模量（FM）。拍摄射线照片以确定聚合物的射线可透性，并使用铝阶跃楔形（0.5-4mm）作为校准标准。使用单种生物膜模型，以变形链球菌作为测试生物，评估聚合物的抗菌性能。在所有测试中，不添加 DDMAI 的 Bis-GMA/TEGDMA 用作对照材料。
方差分析显示，含有和不含有 DDMAI 的聚合物之间的 DC 没有显著差异（p>0.05）。含有 3wt.%DDMAI 的聚合物的 FS 高于对照材料（p<0.05），而含有 5wt.%DDMAI 的聚合物的 FS 与对照材料相当（p>0.05）。虽然对照材料的平均 FM 低于含 3wt.%DDMAI 的聚合物，高于含 5wt.%DDMAI 的聚合物，但差异无统计学意义。随着 DDMAI 用量的增加，聚合物的射线可透性增加。在这三种配方中，含有 5wt.%DDMAI 的聚合物抑制了临床相关年轻生物膜的形成。
将 DDMAI 掺入树脂系统可以赋予其射线可透性和抗菌效果，并且这两种性能似乎随着 DDMAI 用量的增加而提高。
