WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
Clin Biochem. 2012 Aug;45(12):887-93. doi: 10.1016/j.clinbiochem.2012.05.001. Epub 2012 May 8.
Having traditionally relied on measurements of bone mineral density, it is now established that the consideration of other risk variables improves the categorisation of fracture risk. Whereas several models are available, the FRAX models are the most extensively used. The approach uses easily obtained clinical risk factors to estimate 10 year fracture probability, with or without femoral neck bone mineral density (BMD), to enhance fracture risk prediction. It has been constructed and validated using primary data from population based cohorts around the world, including centres from North America, Europe, Asia and Australia. The FRAX® tool should not be considered as a gold standard, but rather as a platform technology on which to build as new validated risk indicators become available. Notwithstanding, the present models provide an aid to enhance patient assessment by the integration of clinical risk factors alone and/or in combination with BMD.
长期以来，人们一直依赖于骨密度的测量，但现在已经确定，考虑其他风险变量可以改善骨折风险的分类。虽然有几种模型可供选择，但 FRAX 模型是应用最广泛的。该方法使用易于获得的临床危险因素来估计 10 年骨折概率，无论是否有股骨颈骨密度（BMD），以增强骨折风险预测。它是使用来自世界各地的基于人群的队列的原始数据构建和验证的，包括来自北美、欧洲、亚洲和澳大利亚的中心。FRAX®工具不应被视为金标准，而应被视为一个平台技术，以便在新的经过验证的风险指标可用时进行构建。尽管如此，目前的模型通过单独或联合使用临床危险因素来增强患者评估提供了一种辅助手段，以及/或者结合 BMD。
