Hooghiemstra Astrid M, Eggermont Laura H P, Scheltens Philip, van der Flier Wiesje M, Scherder Erik J A
Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands.
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):132-45. doi: 10.1159/000335493. Epub 2012 Apr 14.
BACKGROUND/AIMS: Although studies show a negative relationship between physical activity and the risk for cognitive impairment and late-onset Alzheimer's disease, studies concerning early-onset Alzheimer's disease (EOAD) are lacking. This review aims to justify the value of exercise interventions in EOAD by providing theoretical considerations that include neurobiological processes.
A literature search on key words related to early-onset dementia, exercise, imaging, neurobiological mechanisms, and cognitive reserve was performed.
RESULTS/CONCLUSION: Brain regions and neurobiological processes contributing to the positive effects of exercise are affected in EOAD and, thus, provide theoretical support for exercise interventions in EOAD. Finally, we present the design of a randomized controlled trial currently being conducted in early-onset dementia patients.
背景/目的：尽管研究表明身体活动与认知障碍及晚发性阿尔茨海默病风险之间存在负相关关系，但关于早发性阿尔茨海默病（EOAD）的研究却很匮乏。本综述旨在通过提供包括神经生物学过程在内的理论依据，来证明运动干预在早发性阿尔茨海默病中的价值。
对与早发性痴呆、运动、影像学、神经生物学机制及认知储备相关的关键词进行文献检索。
结果/结论：早发性阿尔茨海默病会影响那些对运动产生积极影响的脑区和神经生物学过程，因此为早发性阿尔茨海默病的运动干预提供了理论支持。最后，我们介绍了一项目前正在早发性痴呆患者中进行的随机对照试验的设计。
