Wang J J, Satoh H, Takahashi H, Hasegawa A
Institute of Dermatology, Shanghai Medical University, China.
Mycoses. 1990 Jun;33(6):311-5. doi: 10.1111/myc.1990.33.6.311.
A 34-year-old female farmer suffered from localized cutaneous mucormycosis for 17 years. At the first admission, the lesion was a dull red plaque, about 7 x 9 cm in size with ulcerations, surrounded by some nodules on the dorsum of her right hand. General examination did not reveal abnormal findings except the skin lesion. Direct examination of skin scrapings in 10% KOH revealed broad, sparsely septate, branching hyphae. Histopathology showed many intradermal granulomata and microabscesses as well as mycelial elements comprising broad, distorted, ribbon-like strands. Some of them were phagocytized by multi-nucleated giant cells. Cultures revealed rapidly growing yellow colonies on Sabouraud dextrose agar medium at 25 degrees C. Sporangiophores branched in sympodia and the sporangia were globose, 35-60 microns in diameter. Their walls were deliquescent, but some of them were rather persistent. Columellae were mostly globose, 12-17 microns in diameter, up to 35 microns with collars. Sporangiospores were mainly ellipsoidal, 1.5-2.5 x 3-5 microns in size, but sometimes highly variable in size and shape. The maximum growth temperature of the isolate was 37 degrees C. The pathogenic organism isolated was tentatively identified as Mucor lusitanicus, which, as far as we know, has not been reported as a causative agent of cutaneous mucormycosis.
一名34岁的女性农民患局限性皮肤毛霉病17年。首次入院时，病变为暗红色斑块，大小约7×9厘米，有溃疡，右手背周围有一些结节。除皮肤病变外，全身检查未发现异常。10%氢氧化钾直接检查皮肤刮屑发现宽大、分隔稀疏、有分支的菌丝。组织病理学显示许多真皮内肉芽肿和微脓肿以及由宽大、扭曲、带状菌丝组成的菌丝成分。其中一些被多核巨细胞吞噬。培养显示在25℃的沙氏葡萄糖琼脂培养基上菌落生长迅速，呈黄色。孢囊梗以合轴方式分支，孢子囊呈球形，直径35-60微米。它们的壁易消解，但有些相当持久。囊轴大多呈球形，直径12-17微米，有领时可达35微米。孢子囊孢子主要呈椭圆形，大小为1.5-2.5×3-5微米，但有时大小和形状变化很大。分离株的最高生长温度为37℃。分离出的致病生物初步鉴定为葡萄牙毛霉，据我们所知，尚未有作为皮肤毛霉病病原体的报道。
