Weitzman I, Della-Latta P, Housey G, Rebatta G
Clinical Microbiology Service, Columbia-Presbyterian Medical Center, Columbia University, New York, New York.
J Clin Microbiol. 1993 Sep;31(9):2523-5. doi: 10.1128/jcm.31.9.2523-2525.1993.
Mucor ramosissimus Samutsevitsch is presented for the first time as an etiologic agent of cutaneous zygomycosis in a patient with aplastic anemia on immunosuppressive therapy. This report also represents the third case caused by this species reported in the literature. A biopsy taken from a lesion on the patient's thigh revealed broad, nonseptate, nonbranching hyphae compatible in morphology with a Zygomycete; M. ramosissimus was cultured twice from the thigh lesion. The patient was treated successfully with amphotericin B. Identifying features of M. ramosissimus include the following: numerous sporangia lacking columellae and resembling those of Mortierella spp., short, erect sporangiophores repeatedly branching sympodially; tough, persistent, and diffluent sporangial walls; numerous oidia in chains; extremely low colonies; and restricted growth at 36 degrees C. This paper describes the isolate and strives to alert the clinical microbiologist to this rarely reported pathogen.
分枝毛霉首次作为免疫抑制治疗的再生障碍性贫血患者皮肤接合菌病的病原体被报道。本报告也是文献中报道的由该菌种引起的第三例病例。从患者大腿病变处取的活检显示有宽大、无隔膜、无分支的菌丝，其形态与接合菌相符；分枝毛霉从大腿病变处培养了两次。患者用两性霉素B成功治疗。分枝毛霉的鉴别特征如下：大量缺乏孢囊轴且类似于被孢霉属的孢子囊，短的直立孢囊梗反复呈合轴分枝；坚韧、持久且易消解的孢子囊壁；链状的大量粉孢子；菌落极低；以及在36摄氏度下生长受限。本文描述了该分离株，并努力提醒临床微生物学家注意这种罕见报道的病原体。
