钯催化的炔丙基碳酸酯和仲胺合成 2-氨基酮。
Palladium-catalyzed synthesis of 2-amino ketones from propargylic carbonates and secondary amines.
机构信息
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy.
出版信息
Org Biomol Chem. 2012 Jun 28;10(24):4699-703. doi: 10.1039/c2ob25670c. Epub 2012 May 18.
PMID:22596084
Abstract
A novel palladium-catalyzed approach to 2-amino ketones from arylpropargylic carbonates bearing neutral, electron-rich, and electron-poor aromatic rings and cyclic secondary amines containing useful functional groups such as cyano, chloro, and bromo substituents has been developed.
摘要
开发了一种新型钯催化方法，可从带有中性、富电子和缺电子芳环的芳基丙炔碳酸酯和含有氰基、氯和溴取代基等有用官能团的环状仲胺合成 2-氨基酮。
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