Department of Medical Oncology, University Medical Center Utrecht, The Netherlands.
Br J Cancer. 2012 Jun 5;106(12):1901-6. doi: 10.1038/bjc.2012.201. Epub 2012 May 17.
It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance.
越来越明显的是，肿瘤微环境在肿瘤进展和耐药性方面起着非常重要的作用。肿瘤基质中的许多不同类型的细胞对肿瘤进展有积极或消极的影响。间充质干细胞（MSCs）是一种与肿瘤生长有关的特殊细胞群。间充质干细胞可以归巢到肿瘤中，在那里它们调节免疫系统并促进肿瘤生长、血管生成和转移。最近的研究表明，MSCs 也在对抗各种抗癌药物的耐药性方面发挥着重要作用。这篇迷你综述概述了 MSCs 在肿瘤进展和耐药性中的功能特性。
