局部应用芦荟和金盏花治疗儿童尿布皮炎疗效的随机对照试验。
A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children.
作者信息
Panahi Yunes, Sharif Mohamad Reza, Sharif Alireza, Beiraghdar Fatemeh, Zahiri Zahra, Amirchoopani Golnoush, Marzony Eisa Tahmasbpour, Sahebkar Amirhossein
机构信息
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
出版信息
ScientificWorldJournal. 2012;2012:810234. doi: 10.1100/2012/810234. Epub 2012 Apr 19.
INTRODUCTION
Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children.
METHODS
Sixty-six infants with DD (aged < 3 years) were randomized to receive either aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.
RESULTS
Although improvement in the severity of DD was observed in both treatment groups (P < 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to aloe group (P = 0.001). No adverse effect was reported from either of the medications.
DISCUSSION
The evidence from this study suggests that topical aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.
引言
尿布皮炎（DD）是婴幼儿常见的炎症性疾病。本随机双盲试验的目的是比较芦荟乳膏和金盏花软膏对儿童尿布皮炎的发生频率和严重程度的治疗效果。
方法
66例尿布皮炎婴儿（年龄<3岁）被随机分为两组，分别接受芦荟乳膏治疗（n = 32）或金盏花软膏治疗（n = 34）。婴儿每天使用这些药物3次，持续10天。在基线和试验结束时，使用5分制对皮炎严重程度进行分级。在试验期间评估研究药物的不良反应。
结果
虽然两个治疗组的尿布皮炎严重程度均有改善（P < 0.001），但与芦荟组相比，接受金盏花软膏治疗的患者皮疹部位明显更少（P = 0.001）。两种药物均未报告不良反应。
讨论
本研究证据表明，局部应用芦荟尤其是金盏花可作为治疗婴儿尿布皮炎的安全有效方法。
Zotero 插件