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经口机器人手术在口咽癌治疗中的作用:文献综述

The role of transoral robotic surgery in the management of oropharyngeal cancer: a review of the literature.

作者信息

Dowthwaite Samuel A, Franklin Jason H, Palma David A, Fung Kevin, Yoo John, Nichols Anthony C

机构信息

Department of Otolaryngology-Head and Neck Surgery, The University of Western ON, London, ON, Canada N6A 3K7.

出版信息

ISRN Oncol. 2012;2012:945162. doi: 10.5402/2012/945162. Epub 2012 Apr 23.

Abstract

Background. Transoral robotic surgery (TORS) is an emerging treatment option for the treatment of head and neck malignancies, particularly for oropharyngeal squamous cell carcinoma (OPSCC). Preliminary studies have demonstrated excellent oncologic and functional outcomes that have led to a resurgence of interest in the primary surgical management of OPSCC. The aim of the present study was to review the evidence base supporting the use of TORS in OPSCC. Methods. Studies evaluating the application of TORS in the treatment of head and neck squamous cell carcinoma (HNSCC), and more specifically OPSCC, were identified for review. Further searches were made of reference lists for complete evaluation of minimally invasive surgery (MIS) in treating OPSCC. Results. Seventeen results relating to the application of TORS in treatment of OPSCC were identified. Further results relating to the role of transoral laser microsurgery (TLM) in OPSCC were included for review. Feasibility, oncologic, and functional data is summarized and discussed. Discussion. Management strategies for patients with OPSCC continue to evolve. Minimally invasive surgical techniques including TORS and TLM offer impressive functional and oncologic outcomes particularly for patients with early T-classification and low-volume regional metastatic disease. Potential exists for treatment deintensification, particularly in patients who are HPV positive.

摘要

背景。经口机器人手术(TORS)是治疗头颈部恶性肿瘤,尤其是口咽鳞状细胞癌(OPSCC)的一种新兴治疗选择。初步研究已证明其具有出色的肿瘤学和功能学结果,这使得人们对OPSCC的原发性手术治疗重新产生了兴趣。本研究的目的是回顾支持在OPSCC中使用TORS的证据基础。方法。确定了评估TORS在治疗头颈部鳞状细胞癌(HNSCC),更具体地说是OPSCC中的应用的研究进行综述。进一步检索参考文献列表以全面评估微创手术(MIS)在治疗OPSCC中的作用。结果。确定了17项关于TORS在治疗OPSCC中的应用的结果。还纳入了关于经口激光显微手术(TLM)在OPSCC中的作用的进一步结果进行综述。总结并讨论了可行性、肿瘤学和功能学数据。讨论。OPSCC患者的管理策略在不断发展。包括TORS和TLM在内的微创手术技术尤其为早期T分期和低容量区域转移性疾病的患者提供了令人印象深刻的功能和肿瘤学结果。存在治疗强度降低的可能性,尤其是对于HPV阳性的患者。

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本文引用的文献

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Transoral robotic surgery for head and neck cancer: a series of 17 cases.经口机器人手术治疗头颈部肿瘤:系列 17 例报道。
Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Dec;128(6):290-6. doi: 10.1016/j.anorl.2011.05.002. Epub 2011 Sep 28.
4
The mutational landscape of head and neck squamous cell carcinoma.头颈部鳞状细胞癌的突变全景。
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