经口机器人手术与放疗对口咽癌患者吞咽功能的影响：一项随机试验的子研究
Impact of Transoral Robotic Surgery Versus Radiation on Swallowing Function in Oropharyngeal Cancer Patients: A Sub-Study From a Randomized Trial.
作者信息
Theurer Julie A, Martino Rosemary, Jovanovic Nedeljko, de Almeida John R, Goldstein David P, Fung Kevin, Yoo John, MacNeil S Danielle, Winquist Eric, Hammond J Alex, Venkatesan Varagur, Read Nancy, Kuruvilla Sarah, Warner Andrew, Doyle Philip C, Ross Ian, Dreyer Colleen, Hawkins Sarah, Thouless Kendra, McCallum Courtney, Palma David A, Nichols Anthony C
机构信息
School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.
Department of Otolaryngology - Head and Neck Surgery, Western University, London, Ontario, Canada.
出版信息
Head Neck. 2025 Mar;47(3):906-916. doi: 10.1002/hed.27986. Epub 2024 Nov 4.
BACKGROUND
This ORATOR sub-study evaluated swallowing physiology in patients treated with transoral robotic surgery (TORS) versus radiotherapy (RT) for early-stage oropharynx cancer.
METHODS
Swallowing physiology was evaluated using videofluoroscopy and outcomes were compared across treatment arms and correlated with MDADI scores.
RESULTS
Of the 68 patients in the ORATOR trial, 21 participated in this sub-study (30.8%), including 15 RT Arm and six TORS Arm patients. Swallowing profiles were not significantly different between the arms. MBSImP pharyngeal scores for RT Arm versus TORS Arm patients were 4.8 (±2.1) versus 4.3 (±1.5) at baseline, 6.2 (±1.2) versus 9.6 (±4.8) at 6 months and 5.9 (±1.8) versus 8.0 (±4.7) at 12 months. MBSImP pharyngeal scores demonstrated weak associations with several MDADI subscales and PAS scores.
CONCLUSIONS
To best describe swallowing outcomes in studies of RT and/or surgery, instrumental swallowing assessments should be strongly considered in addition to quality of life measures.
背景
本ORATOR子研究评估了经口机器人手术（TORS）与放射治疗（RT）治疗早期口咽癌患者的吞咽生理学。
方法
使用视频荧光透视法评估吞咽生理学，并比较各治疗组的结果，并与MDADI评分相关联。
结果
在ORATOR试验的68例患者中，21例参与了本子研究（30.8%），包括15例RT组和6例TORS组患者。两组之间的吞咽情况无显著差异。RT组与TORS组患者的MBSImP咽部评分在基线时分别为4.8（±2.1）和4.3（±1.5），6个月时分别为6.2（±1.2）和9.6（±4.8），12个月时分别为5.9（±1.8）和8.0（±4.7）。MBSImP咽部评分与几个MDADI子量表和PAS评分之间存在弱关联。
结论
为了最好地描述RT和/或手术研究中的吞咽结果，除生活质量测量外，还应强烈考虑仪器吞咽评估。
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