Department of Dermatology, University of Sao Paulo Medical School, São Paulo-SP, Brazil.
Int J Dermatol. 2012 Jun;51(6):672-6. doi: 10.1111/j.1365-4632.2011.05176.x.
Atopic dermatitis (AD) is a chronic dermatosis, predominant in childhood, characterized by pruritus and eczematous-type lesions with xerosis as the prominent clinical sign.
To analyze the correlation between biophysical measurements of skin barrier function and other assessment criteria of clinical severity according to Rajka and Langeland's criteria.
Biophysical measurements [transepidermal water loss (TEWL) and corneometry] were obtained from 120 patients with the diagnosis of AD. Serum levels of IgE were also evaluated.
A significant correlation between corneometry, TEWL, and clinical severity of AD was found. Data showed an inverse correlation between corneometry, TEWL, and AD severity, and a significant difference (P < 0.001) between mean of corneometry and TEWL and AD severity (mild, moderate, and severe). As for IgE levels, corneometry had significant negative correlation, in contrast with TEWL, which showed a significant positive correlation (P < 0.001).
Biophysical measurements of skin barrier in non-lesional skin of AD may work as an evaluation factor for AD severity.
特应性皮炎（AD）是一种慢性皮肤病，主要发生在儿童时期，其特征为瘙痒和湿疹样病变，干燥是其突出的临床征象。
根据 Rajka 和 Langeland 的标准，分析皮肤屏障功能的生物物理测量值与其他临床严重程度评估标准之间的相关性。
对 120 例 AD 患者进行生物物理测量（经皮水分丢失[TEWL]和皮肤角质层水分测量），并检测血清 IgE 水平。
发现皮肤角质层水分测量值、TEWL 值与 AD 严重程度呈显著相关性。数据显示，皮肤角质层水分测量值、TEWL 值与 AD 严重程度呈负相关，差异有统计学意义（P < 0.001）；皮肤角质层水分测量值和 TEWL 值与 AD 严重程度之间的差异有统计学意义（轻度、中度和重度）。与 TEWL 相反，IgE 水平与皮肤角质层水分测量值呈显著负相关（P < 0.001）。
AD 非病变皮肤的皮肤屏障生物物理测量值可作为 AD 严重程度的评估因素。
