Field Epidemiology and Laboratory TrainingProgram, Nairobi, Kenya.
Emerg Infect Dis. 2012 Jun;18(6):925-31. doi: 10.3201/eid1806.111774.
Numerous outbreaks of cholera have occurred in Kenya since 1971. To more fully understand the epidemiology of cholera in Kenya, we analyzed the genetic relationships among 170 Vibrio cholerae O1 isolates at 5 loci containing variable tandem repeats. The isolates were collected during January 2009-May 2010 from various geographic areas throughout the country. The isolates grouped genetically into 5 clonal complexes, each comprising a series of genotypes that differed by an allelic change at a single locus. No obvious correlation between the geographic locations of the isolates and their genotypes was observed. Nevertheless, geographic differentiation of the clonal complexes occurred. Our analyses showed that multiple genetic lineages of V. cholerae were simultaneously infecting persons in Kenya. This finding is consistent with the simultaneous emergence of multiple distinct genetic lineages of V. cholerae from endemic environmental reservoirs rather than recent introduction and spread by travelers.
自 1971 年以来，肯尼亚多次爆发霍乱。为了更全面地了解肯尼亚的霍乱流行情况，我们分析了在 5 个包含可变串联重复的基因座中采集的 170 株霍乱弧菌 O1 分离株的遗传关系。这些分离株是在 2009 年 1 月至 2010 年 5 月期间从全国各地的不同地理区域收集的。这些分离株在遗传上分为 5 个克隆复合体，每个复合体由一系列基因型组成，这些基因型在单个基因座上的等位基因变化而有所不同。分离株的地理位置与其基因型之间没有明显的相关性。然而，克隆复合体确实存在地理分化。我们的分析表明，肯尼亚的人群同时感染了多种不同的霍乱弧菌遗传谱系。这一发现与霍乱弧菌从地方性环境储库中同时出现多种不同的遗传谱系一致，而不是旅行者近期的传入和传播。
