Institut Pasteur, Paris, France
Emerg Infect Dis. 2012 Jun;18(6):966-8. doi: 10.3201/eid1806.120091.
A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of the 23S rRNA gene. Monitoring for macrolide resistance is essential in infants <6 months of age.
给一名咳嗽的新生儿使用了一种大环内酯类抗菌药物。住院第 23 天，从鼻咽抽吸物中分离出耐大环内酯类的百日咳博德特氏菌。DNA 测序和 PCR-限制性片段长度多态性显示，23S rRNA 基因的 3 个拷贝中存在 2047 个 A 到 G 的突变。对<6 个月龄婴儿进行大环内酯类耐药监测至关重要。
