Department of Orthopedics, Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.
J Arthroplasty. 2012 Sep;27(8 Suppl):51-4.e1. doi: 10.1016/j.arth.2012.03.021. Epub 2012 May 17.
Serum white blood cell (WBC) count and neutrophil differential are frequently ordered during preoperative workup of suspected cases of periprosthetic joint infection (PJI). However, their roles in diagnosis of PJI have remained unclear despite previous studies. In this study, preoperative serum WBC and neutrophil percentages were retrieved from hospital charts. The diagnostic cutoff point determined by receiver operating characteristic curve analysis was 7800 cells/μL with 55% sensitivity and 66% specificity for WBC count, whereas the cutoff value for neutrophil percentage was 68% with 52% sensitivity and 75% specificity. Our study confirms the long-held belief that serum WBC count and differential has minimal role in routine workup of patients with suspected PJI.
术前检查疑似人工关节感染（PJI）时，常检测血清白细胞（WBC）计数和中性粒细胞分类。然而，尽管之前有研究，但它们在 PJI 诊断中的作用仍不清楚。在本研究中，从病历中检索术前血清 WBC 和中性粒细胞百分比。通过受试者工作特征曲线分析确定的诊断截断值为 7800 个细胞/μL，WBC 计数的敏感性为 55%，特异性为 66%，而中性粒细胞百分比的截断值为 68%，敏感性为 52%，特异性为 75%。我们的研究证实了长期以来的观点，即血清 WBC 计数和分类在疑似 PJI 患者的常规检查中作用有限。
