Cancer and Inflammation Program, Laboratory of Experimental Immunology, NCI-Frederick, Frederick, MD 21702, USA.
Hum Immunol. 2012 Aug;73(8):783-7. doi: 10.1016/j.humimm.2012.05.006. Epub 2012 May 17.
While most carriers of human T-cell leukemia virus type 1 (HTLV-1) remain asymptomatic throughout their lifetime, infection is associated with the development of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact parameters that determine these outcomes are unknown but are believed to include host genetic factors that control the immune response to infection. Host response to fellow retroviridae member HIV is influenced by the expression of members of the Killer Immunoglobulin Receptor (KIR) family including KIR3DS1. In this study we examined the association of KIR3DS1 with the outcome of HTLV-1 infection in three geographically distinct cohorts (Jamaican, Japanese and Brazilian). Despite increased prevalence of KIR3DS1 in the HAM/TSP patients of the Jamaican cohort, we found no evidence for a role of KIR3DS1 in influencing control of proviral load or disease outcome. This suggests that unlike HIV, KIR3DS1-mediated regulation of HTLV-1 infection does not occur, or is ineffective.
虽然大多数人类 T 细胞白血病病毒 1 型（HTLV-1）携带者在其一生中都没有症状，但感染与成人 T 细胞白血病（ATL）和 HTLV-1 相关的脊髓病/热带痉挛性截瘫（HAM/TSP）的发展有关。确定这些结果的确切参数尚不清楚，但据信包括控制感染免疫反应的宿主遗传因素。宿主对同属逆转录病毒科的 HIV 的反应受到杀伤免疫球蛋白受体（KIR）家族成员的表达的影响，包括 KIR3DS1。在这项研究中，我们在三个地理位置不同的队列（牙买加、日本和巴西）中检查了 KIR3DS1 与 HTLV-1 感染结果之间的关联。尽管牙买加队列的 HAM/TSP 患者中 KIR3DS1 的患病率增加，但我们没有发现 KIR3DS1 对控制前病毒载量或疾病结果有影响的证据。这表明与 HIV 不同，KIR3DS1 介导的 HTLV-1 感染调控不存在，或者无效。
