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用于基于 2.1MeV 质子加速器的硼中子俘获治疗的中子源的优化束流成形组件。

Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy.

机构信息

Departamento de Física Atómica, Molecular y Nuclear, Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain.

出版信息

Sci Rep. 2021 Apr 7;11(1):7576. doi: 10.1038/s41598-021-87305-9.

Abstract

Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.

摘要

硼中子俘获治疗(BNCT)正面临一个新时期,基于加速器而非反应堆的不同项目正在开发中。新设施可以放置在医院,并将增加临床试验的数量。如果获得优化的超热中子能谱,BNCT 的治疗效果可以得到改善,而束流形状组件是关键因素。在本文中,我们提出了一种适用于经济实惠的低能加速器的优化束流形状组件。该装置获得的束流满足了国际原子能机构(IAEA)对质子能量在 2.0 和 2.1 MeV 之间的所有建议。此外,与 BNCT 设施以及之前提出的基于新加速器设施的建议相比,整体上提高了最佳指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6484/8026976/bf113820005e/41598_2021_87305_Fig2_HTML.jpg

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