Department of Biology, University of Turku, Biocity A, Tykistökatu 6A, FI-20520 Turku, Finland.
Biotechnol Genet Eng Rev. 2012;28:61-100. doi: 10.5661/bger-28-61.
Unlike in animal cells and yeasts, the Ras and Rho small G proteins and their regulators have not received extensive research attention in the case of the filamentous fungi. In an effort to begin to rectify this deficiency, the genome sequence of the basidiomycete mushroom Schizophyllum commune was searched for all known components of the Ras and Rho signalling pathways. The results of this study should provide an impetus for further detailed investigations into their role in polarized hyphal growth, sexual reproduction and fruiting body development. These processes have long been the targets for genetic and cell biological research in this fungus.
与动物细胞和酵母不同，丝状真菌中 Ras 和 Rho 小 G 蛋白及其调节因子并未受到广泛关注。为了弥补这一不足，我们对担子菌蘑菇 Schizophyllum commune 的基因组进行了搜索，以寻找 Ras 和 Rho 信号通路的所有已知成分。这项研究的结果将为进一步深入研究它们在菌丝极性生长、有性生殖和子实体发育中的作用提供动力。长期以来，这些过程一直是该真菌中遗传和细胞生物学研究的目标。
