Department of General Surgery, Section of Transplantation, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Dig Liver Dis. 2012 Sep;44(9):714-20. doi: 10.1016/j.dld.2012.04.005. Epub 2012 May 22.
The present review aims to illustrate the strategies that are being implemented in regenerative medicine to treat diseases that affect the digestive tract. Possible avenues are twofold: organ bioengineering, where cells are seeded on biological or synthetic scaffolding materials ex vivo and allowed to either mature in bioreactors or be implanted without undergoing any maturation; and regeneration per se, where the diseased tissue or organ is regenerated by recapitulation of its multi-step ontogenesis. This latter avenue may be induced either in vivo or ex vivo. While bioengineering technology has already manufactured segments of the digestive tract and sphincters, pure regeneration of any segment of the digestive tract has not yet been described. However, models of regeneration extrapolated from simple organisms are elucidating the complex yet fascinating mechanisms that regulate the ontogenesis of the digestive tract and are paving the way for the development of new regenerative technologies and methods.
本文旨在阐述再生医学中用于治疗消化道疾病的策略。可能的途径有两种：器官生物工程，即将细胞接种在生物或合成支架材料上，在体外进行成熟，或者在不经过任何成熟过程的情况下进行植入；以及本身的再生，即通过再现其多步发生过程来再生患病组织或器官。后一种途径可以在体内或体外诱导。虽然生物工程技术已经制造出消化道的某些部分和括约肌，但尚未描述任何消化道部分的纯再生。然而，从简单生物体推断出的再生模型正在阐明调节消化道发生的复杂而迷人的机制，并为开发新的再生技术和方法铺平了道路。
