Bitar Khalil N, Zakhem Elie
a Wake Forest Institute for Regenerative Medicine , Wake Forest School of Medicine , Winston Salem , NC , USA.
b Department of Molecular Medicine and Translational Sciences , Wake Forest School of Medicine , Winston Salem , NC , USA.
Expert Rev Gastroenterol Hepatol. 2015;9(12):1463-5. doi: 10.1586/17474124.2015.1103178. Epub 2015 Nov 2.
The gastrointestinal (GI) tract is responsible for conducting multiple functions including motility, digestion and absorption. In gastrointestinal disorders, some of those functions are weakened or lost. Excision of the diseased segment of the GI tract is a common treatment; however, patients suffer from complications and low quality of life. Functional replacements are therefore needed to restore, repair or replace damaged parts of the tract. Tissue engineering and regenerative medicine provide an alternative approach to reconstruct different segments of the GI tract. The GI tract is a complex system with multiple cell types and layers. In previous years, bioengineering approaches focused on identifying an optimal cell source and scaffolding material to engineer GI tissues. In this editorial, we address some of our thoughts with regard to the recent discoveries in bioengineering the GI tract.
胃肠道负责执行多种功能，包括蠕动、消化和吸收。在胃肠道疾病中，其中一些功能会减弱或丧失。切除胃肠道的病变部分是一种常见的治疗方法；然而，患者会出现并发症且生活质量较低。因此，需要功能性替代物来恢复、修复或替换胃肠道受损的部分。组织工程和再生医学为重建胃肠道的不同部分提供了一种替代方法。胃肠道是一个由多种细胞类型和层组成的复杂系统。在过去几年中，生物工程方法专注于确定用于构建胃肠道组织的最佳细胞来源和支架材料。在这篇社论中，我们阐述了一些关于胃肠道生物工程最新发现的想法。
