受体酪氨酸激酶在发育和癌症中的空间调控。
Spatial regulation of receptor tyrosine kinases in development and cancer.
机构信息
MGH Center for Cancer Research, Charlestown, MA 02129, USA.
出版信息
Nat Rev Cancer. 2012 May 24;12(6):387-400. doi: 10.1038/nrc3277.
Abstract
During development and tissue homeostasis, patterns of cellular organization, proliferation and movement are highly choreographed. Receptor tyrosine kinases (RTKs) have a crucial role in establishing these patterns. Individual cells and tissues exhibit tight spatial control of the RTKs that they express, enabling tissue morphogenesis and function, while preventing unwarranted cell division and migration that can contribute to tumorigenesis. Indeed, RTKs are deregulated in most human cancers and are a major focus of targeted therapeutics. A growing appreciation of the essential role of spatial RTK regulation during development prompts the realization that spatial deregulation of RTKs is likely to contribute broadly to cancer development and may affect the sensitivity and resistance of cancer to pharmacological RTK inhibitors.
摘要
在发育和组织稳态过程中，细胞组织、增殖和运动的模式高度协调。受体酪氨酸激酶（RTKs）在建立这些模式方面起着至关重要的作用。单个细胞和组织对其表达的 RTKs 具有严格的空间控制，从而使组织形态发生和功能正常，同时防止可能导致肿瘤发生的不必要的细胞分裂和迁移。事实上，RTKs 在大多数人类癌症中失调，是靶向治疗的主要焦点。对 RTK 空间调控在发育过程中的重要作用的认识不断加深，促使人们认识到 RTK 的空间失调可能广泛促进癌症的发展，并可能影响癌症对药理学 RTK 抑制剂的敏感性和耐药性。
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