Fathi Mohammadhossein, Ahmadian Mehdi, Bahrami Mojgan
Department of Materials Engineering, Biomaterials Research Group, Isfahan University of Technology, 8415683111 Isfahan, Iran.
Dent Res J (Isfahan). 2012 Mar;9(2):173-9. doi: 10.4103/1735-3327.95232.
Dental cobalt base alloys are biocompatible dental materials and have been widely used in dentistry. However, metals are bioinert and may not present bioactivity in human body. Bioactivity is the especial ability to interact with human body and make a bonding to soft and hard tissues. The aim of the present research was fabrication and bioactivity evaluation of novel cobalt alloy/Fluorapatite nanocomposite (CoA/FaNC) with different amounts of Fluorapatite (FA) nanopowder.
Co-Cr-Mo alloy (ASTM F75) powder was prepared and mixed in a planetary ball mill with different amounts of FA nanopowders (10, 15, 20% wt). Prepared composite powders were cold pressed and sintered at 1100°C for 4 h. X-ray diffraction (XRD), scanning electron microscopy and transition electron microscopy techniques were used for phase analysis, crystallite size determination of FA and also for phase analysis and evaluation of particle distribution of composites. Bioactivity behavior of prepared nanocomposites was evaluated in simulated body fluid (SBF) for 1 up to 28 days.
Co-Cr-Mo alloy (ASTM F75) powder was prepared and mixed in a planetary ball mill with different amounts of FA nanopowders (10, 15, 20% wt). Prepared composite powders were cold pressed and sintered at 1100°C for 4 h. X-ray diffraction (XRD), scanning electron microscopy and transition electron microscopy techniques were used for phase analysis, crystallite size determination of FA and also for phase analysis and evaluation of particle distribution of composites. Bioactivity behavior of prepared nanocomposites was evaluated in simulated body fluid (SBF) for 1 up to 28 days.
Results showed that nucleus of apatite were formed on the surface of the prepared CoA/FaNC during 1 up to 28 days immersion in the SBF solution. On the other hand, CoA/FaNC unlike Co-base alloy possessed bone-like apatite-formation ability.
It was concluded that bioinert Co-Cr-Mo alloy could be successfully converted into bioactive nanocomposite by adding 10, 15, 20 wt% of FA nano particles.
牙科钴基合金是具有生物相容性的牙科材料,已在牙科领域广泛应用。然而,金属具有生物惰性,在人体中可能不具备生物活性。生物活性是指与人体相互作用并与软硬组织形成结合的特殊能力。本研究的目的是制备并评估含有不同含量氟磷灰石(FA)纳米粉末的新型钴合金/氟磷灰石纳米复合材料(CoA/FaNC)的生物活性。
制备Co-Cr-Mo合金(ASTM F75)粉末,并在行星式球磨机中与不同含量(10%、15%、20%重量)的FA纳米粉末混合。将制备好的复合粉末进行冷压,并在1100°C下烧结4小时。采用X射线衍射(XRD)、扫描电子显微镜和透射电子显微镜技术进行相分析、测定FA的微晶尺寸,以及对复合材料的相分析和颗粒分布评估。将制备好的纳米复合材料置于模拟体液(SBF)中1至28天,以评估其生物活性行为。
结果表明,在将制备的CoA/FaNC浸泡于SBF溶液的1至28天内,其表面形成了磷灰石晶核。另一方面,CoA/FaNC与钴基合金不同,具有形成类骨磷灰石的能力。
得出的结论是,通过添加10%、15%、20%重量的FA纳米颗粒,可成功将生物惰性的Co-Cr-Mo合金转化为生物活性纳米复合材料。