Manafi Sahebali, Mirjalili Fatemeh, Reshadi Rayhaneh
Department of Materials Engineering, Shahrood Branch, Islamic Azad University, Shahrood, Iran.
Department of Materials Engineering, Maybod Branch, Islamic Azad University, Maybod, Iran.
Prog Biomater. 2019 Jun;8(2):77-89. doi: 10.1007/s40204-019-0112-y. Epub 2019 Apr 11.
This research study concerns the evaluations of nano-biocomposite ceramics' characteristics and biocompatibility. A nanocomposite with 45S5 bioactive glass base has been synthesized by sol-gel method. The synthesized nanocomposites were characterized with the help of different techniques, using field-emission scanning electron microscope, X-ray powder diffraction, energy-dispersive X-ray spectroscopy to evaluate the crystal structure, microstructure, and the morphology of the nanocomposite. The results indicated that the synthesis of 45S5 bioactive glass-fluorapatite nanocomposites produced an average particle size of about 20-30 nm and percentages of crystallinity of about 70-90%. fluorapatite-45S5 bioactive glass nanocomposites were characterized in terms of their degradation by determining the weight change percentages, pH changes, the ion release and in terms of bioactivity by checking the apatite layer formation using a solution of simulated body fluid (SBF). The results showed non-cytotoxicity and the formation of a thick apatite layer on the synthesized nanocomposites within 28 days after soaking in SBF. This is an indication of desirable bioactivity in the synthesized particles.
本研究涉及纳米生物复合陶瓷的特性及生物相容性评估。采用溶胶 - 凝胶法合成了以45S5生物活性玻璃为基的纳米复合材料。借助不同技术对合成的纳米复合材料进行了表征，使用场发射扫描电子显微镜、X射线粉末衍射、能量色散X射线光谱来评估纳米复合材料的晶体结构、微观结构和形态。结果表明，45S5生物活性玻璃 - 氟磷灰石纳米复合材料的合成产生了平均粒径约为20 - 30纳米、结晶度约为70 - 90%的产物。通过测定重量变化百分比、pH变化、离子释放来表征氟磷灰石 - 45S5生物活性玻璃纳米复合材料的降解情况，并通过使用模拟体液（SBF）溶液检查磷灰石层形成来表征其生物活性。结果显示，在浸泡于SBF中28天内，合成的纳米复合材料具有无细胞毒性且形成了厚磷灰石层。这表明合成颗粒具有理想的生物活性。
