提高印度的艾滋病毒药物依从性。
Enhancing HIV medication adherence in India.
作者信息
Jones Deborah, Sharma Aman, Kumar Mahendra, Waldrop-Valverde Drenna, Nehra Ritu, Vamos Szonja, Cook Ryan, Weiss Stephen M
机构信息
Miller School of Medicine, University of Miami, Miami, FL, USA.
出版信息
J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):343-8. doi: 10.1177/1545109712446177. Epub 2012 May 24.
BACKGROUND
This pilot study evaluated an intervention designed to enhance adherence among those new to antiretroviral therapy.
METHODS
Participants (n = 80) were recruited from a hospital clinic in Chandigarh, India, and randomized to a 3-month group intervention or individual enhanced standard of care followed by crossover of condition and assessed over 6 months. Adherence was measured by prescription refill, pill count, and self-report.
RESULTS
At baseline, 56% of group condition (immediate intervention) and 54% of individual condition (delayed intervention) participants were nonadherent by pill count and 23% of group and 26% of individual condition participants self-reported skipping medication at least once over the last 3 months. From the postintervention to long-term follow-up, adherence in the group condition (immediate intervention) improved in comparison with adherence in the individual condition (delayed intervention; χ(2) = 5.67, P = .02).
CONCLUSIONS
Results support the use of interventions early in treatment to provide information and social support to establish long-term healthy adherence behaviors.
背景
这项初步研究评估了一项旨在提高抗逆转录病毒治疗新手依从性的干预措施。
方法
从印度昌迪加尔的一家医院诊所招募了80名参与者，随机分为3个月的小组干预组或个体强化标准护理组，随后进行条件交叉，并在6个月内进行评估。通过处方 refill、药丸计数和自我报告来衡量依从性。
结果
在基线时，通过药丸计数，小组干预组（即时干预）中有56%的参与者和个体干预组（延迟干预）中有54%的参与者不依从，在过去3个月中，小组干预组中有23%的参与者和个体干预组中有26%的参与者自我报告至少跳过一次药物治疗。从干预后到长期随访，小组干预组（即时干预）的依从性与个体干预组（延迟干预）相比有所改善（χ(2)=5.67，P=.02）。
结论
结果支持在治疗早期使用干预措施，以提供信息和社会支持，从而建立长期健康的依从行为。
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