Bernard B, Preston B, Beaupre P, Elliott K, Sadava D
Biol Neonate. 1977;31(3-4):225-8. doi: 10.1159/000240964.
The developmental progression of thymidine kinase from the electrophoretically slow-migrating 'fetal' forms to the fast-migrating 'adult' form was examined in human serum and fetal liver. In fetal liver, only the fetal forms of the enzyme were present at 17 weeks' gestation. A transitional period followed in that both enzyme forms were identified and by 24 weeks only the adult form was detected in fetal liver. This same enzyme changeover pattern--fetal to transitional to adult--occurred at a later time in human serum as it took place between 30 and 40 weeks' gestation.
在人血清和胎儿肝脏中检测了胸苷激酶从电泳迁移缓慢的“胎儿”形式向迁移快速的“成人”形式的发育进程。在妊娠17周时，胎儿肝脏中仅存在该酶的胎儿形式。随后进入过渡期，两种酶形式均被识别，到24周时，胎儿肝脏中仅检测到成人形式。这种相同的酶转换模式——从胎儿形式到过渡形式再到成人形式——在人血清中出现的时间较晚，发生在妊娠30至40周之间。
