Olsson A, Phalen D
Wildlife Health and Conservation Centre, University of Sydney, Camden, New South Wales, Australia.
Aust Vet J. 2012 Jun;90(6):240-4. doi: 10.1111/j.1751-0813.2012.00907.x. Epub 2012 Mar 30.
Restraint of large estuarine crocodiles is potentially dangerous. Neuromuscular blockers and other immobilising drugs have been used with variable results. Medetomidine has been reported as a reliable, repeatable and reversible immobilisation agent in small estuarine crocodilians.
Two wild and two farmed male animals, between 3.05 and 4.6 m long, were hand-injected into a triceps muscle with a metabolically scaled medetomidine dosage. Immobilisation occurred within 30 min. At the conclusion of the procedures, 70 min after medetomidine administration, three animals were injected with atipamezole IM into the opposite triceps muscle at a dosage based on body surface area. Reversal occurred within 5 min. The fourth animal was intubated prior to reversal of medetomidine and maintained on isoflurane anaesthesia for a gastrotomy. All animals were monitored closely post recovery and then regularly for at least 1 week.
Medetomidine at a metabolically scaled dosage delivered IM into the forelimb was effective for immobilising large estuarine crocodiles for at least 40 min. Atipamezole administered at a dosage calculated as a function of surface area effectively reversed this immobilisation.
对大型河口鳄进行约束具有潜在危险性。神经肌肉阻滞剂和其他麻醉药物的使用效果不一。据报道，美托咪定在小型河口鳄中是一种可靠、可重复且可逆的麻醉剂。
对4只雄性鳄鱼（2只野生、2只养殖，体长在3.05至4.6米之间），按代谢比例计算美托咪定剂量后经手动注射至肱三头肌。30分钟内出现麻醉效果。在操作结束时，即美托咪定给药70分钟后，3只鳄鱼按基于体表面积计算的剂量经肌肉注射阿替美唑至对侧肱三头肌。5分钟内苏醒。第四只鳄鱼在美托咪定苏醒前进行插管，并在异氟烷麻醉下进行胃切开术。所有动物在恢复后密切监测，之后至少定期监测1周。
按代谢比例计算剂量经肌肉注射至前肢的美托咪定对大型河口鳄具有至少40分钟的有效麻醉作用。按体表面积计算剂量给予的阿替美唑能有效逆转这种麻醉状态。
