微小 RNA 工厂：前体微小 RNA 到 RISC 组装
MicroRNA factory: RISC assembly from precursor microRNAs.
机构信息
School of Biological Sciences, Seoul National University, Seoul, Korea.
出版信息
Mol Cell. 2012 May 25;46(4):384-6. doi: 10.1016/j.molcel.2012.05.012.
PMID:22633486
Abstract
RNA silencing requires assembly of an effector complex, RNA-induced silencing complex (RISC), composed of a small RNA and the Ago protein. In this issue of Molecular Cell, Liu et al. (2012) provide insights of miRNP/RISC assembly pathways in mammals, using an in vitro human RISC assembly assay programmed by pre-miRNAs.
摘要
RNA 干扰需要组装一个效应复合物，即 RNA 诱导的沉默复合物 (RISC)，由小 RNA 和 Ago 蛋白组成。在本期《分子细胞》中，刘等人（2012）利用体外人类 RISC 组装测定程序，提供了哺乳动物中 miRNP/RISC 组装途径的见解。
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