Division of Cancer Research, Medical Research Institute, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, United Kingdom.
Cancer Lett. 2012 Nov 28;324(2):126-32. doi: 10.1016/j.canlet.2012.05.011. Epub 2012 May 23.
MAGE-A proteins constitute a sub-family of Cancer-Testis Antigens which are expressed mainly, but not exclusively, in germ cells. They are also expressed in various human cancers where they are associated with, and may drive, malignancy. MAGE-A proteins are highly immunogenic and are considered as potential targets for cancer vaccines and/or immuno-therapy. Moreover, recent advances in our understanding of their molecular pathology have revealed interactions that offer potential as therapeutic targets. Here we review recent progress in this area and consider how these interactions might be exploited, especially for the treatment of malignant cancers for which available treatments are inadequate.
MAGE-A 蛋白构成了癌症睾丸抗原的一个亚家族，主要（但并非专门）在生殖细胞中表达。它们也在各种人类癌症中表达，与恶性肿瘤相关，并可能推动恶性肿瘤的发展。MAGE-A 蛋白具有高度的免疫原性，被认为是癌症疫苗和/或免疫疗法的潜在靶点。此外，我们对其分子病理学的理解的最新进展揭示了可能作为治疗靶点的相互作用。在这里，我们回顾了这一领域的最新进展，并探讨了如何利用这些相互作用，特别是对于治疗现有治疗方法不足的恶性癌症。
