Department of Dermatology, University of Wisconsin, Medical Sciences Center, University Avenue, Madison, WI 53706, USA.
Cancer Lett. 2012 Dec 30;326(2):123-7. doi: 10.1016/j.canlet.2012.05.016. Epub 2012 May 22.
Cancer chemoprevention, based on recent successes both in the laboratory and the clinic, is being considered as a viable option for controlling the disease. This approach takes advantage of the long latency of the disease that offers numerous opportunities for intervention. Chemopreventive intervention caters to a defined population that is relatively at a higher risk for developing the disease with an objective to stop, reverse or slow down the progression of the disease. The strategy of slowing the progression of cancer through chemoprevention could be applicable to many cancers with long latency including prostate cancer. Although cancer chemoprevention has proven to be a successful strategy in animals its application to humans has met only with limited success. This review will debate various challenges associated with chemoprevention of cancer and discuss ways to overcome them.
癌症化学预防，基于实验室和临床的近期成功，被认为是控制疾病的一种可行选择。这种方法利用了疾病的长潜伏期，为干预提供了许多机会。化学预防干预针对的是一个具有较高疾病发病风险的特定人群，目的是阻止、逆转或减缓疾病的进展。通过化学预防减缓癌症进展的策略可能适用于许多潜伏期较长的癌症，包括前列腺癌。虽然癌症化学预防在动物身上已被证明是一种成功的策略，但将其应用于人类仅取得了有限的成功。本综述将讨论与癌症化学预防相关的各种挑战，并探讨克服这些挑战的方法。
